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Paul De Koninck

Paul De Koninck, Ph.D., Principal Investigator, Professor of Biochemistry


Associate Professor, Département de Biochimie, Microbiologie et Bio-Informatique, Université Laval, 2006-now
Assistant Professor, Département de Biochimie et Microbiologie, Université Laval, 2001-2006

Director, Graduate Program in Biophotonics, Université Laval, 2008-now


  • Post-doctoral training, Stanford University, 1995-2001
  • Ph.D. - Neurobiology, McGill University, 1995


Selected Publications

Pi HJ, Otmakhov N, El Gaamouch F, Lemelin D, De Koninck P, Lisman J. CaMKII control of spine size and synaptic strength: role of phosphorylation states and nonenzymatic action. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14437-42. 

Opazo P, Labrecque S, Tigaret CM, Frouin A, Wiseman PW, De Koninck P, Choquet D. CaMKII triggers the diffusional trapping of surface AMPARs through phosphorylation of stargazin. Neuron. 2010 Jul 29;67(2):239-52.

Pi HJ, Otmakhov N, Lemelin D, De Koninck P, Lisman J. Autonomous CaMKII can promote either long-term potentiation or long-term depression, depending on the state of T305/T306 phosphorylation. J Neurosci. 2010 Jun 30;30(26):8704-9.

Heinze KG, Costantino S, De Koninck P, Wiseman PW. Beyond photobleaching, laser illumination unbinds fluorescent proteins. J Phys Chem B. 2009 Apr 16;113(15):5225-33.

Smith BA, Roy H, De Koninck P, Grütter P, De Koninck Y. Dendritic spine viscoelasticity and soft-glassy nature: balancing dynamic remodeling with structural stability. Biophys J. 2007 Feb 15;92(4):1419-30.

Bayer KU, LeBel E, McDonald GL, O'Leary H, Schulman H, De Koninck P. Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B. J Neurosci. 2006 Jan 25;26(4):1164-74.

Hudmon A, Lebel E, Roy H, Sik A, Schulman H, Waxham MN, De Koninck P. A mechanism for Ca2+/calmodulin-dependent protein kinase II clustering at synaptic and nonsynaptic sites based on self-association. J Neurosci. 2005 Jul 27;25(30):6971-83.

Costantino S, Heinze KG, Martínez OE, De Koninck P, Wiseman PW. Two-photon fluorescent microlithography for live-cell imaging. Microsc Res Tech. 2005 Dec 1;68(5):272-6.

Dupont G, Houart G, De Koninck P. Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations: a simple model. Cell Calcium. 2003 Dec;34(6):485-97.

Coull JA, Boudreau D, Bachand K, Prescott SA, Nault F, Sík A, De Koninck P, De Koninck Y. Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature. 2003 Aug 21;424(6951):938-42.

Bayer KU, De Koninck P, Schulman H. Alternative splicing modulates the frequency-dependent response of CaMKII to Ca(2+) oscillations. EMBO J. 2002 Jul 15;21(14):3590-7.

Postdoc years

Bayer KU, De Koninck P, Leonard AS, Hell JW, Schulman H. Interaction with the NMDA receptor locks CaMKII in an active conformation. Nature. 2001 Jun 14;411(6839):801-5.

De Koninck P, Schulman H. Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations. Science. 1998 Jan 9;279(5348):227-30.

De Koninck P, Carbonetto S, Cooper E. NGF induces neonatal rat sensory neurons to extend dendrites in culture after removal of satellite cells. J Neurosci. 1993 Feb;13(2):577-85.